I was recently commissioned to create a set of illustrations to go on construction hoardings around the Euston Station (London) area. I picked Affinity Designer as my weapon of choice, and the results can be seen if you take a wander around the district.
The one small production bummer was that the agency doing the artwork insisted on AI files so I have to convert them all before sending them out. Even despite that I would still have used Affinity for these as it's just a much nicer illustration tool than Adobe. I think these would have taken me twice as long in Illustrator, and given me a migraine along the way.