The help file of Affinity Photo should provide a guideline explaining the differences between these resample modes (the pros and cons).
Furthering the idea proposed by JDW, an interrogation mark should be provided directly in the Resample popup that, when clicked, makes appear an info box explaining these differences and —more importantly— proposes the best mode according to the app maker (Serif).
It's indeed peculiar that such basic information is nonexistent in the help file, in the resample popup, or on the web site of Serif!
I’m in Affinity Photo and this problem of persistent visibility of handles around selected objects is actually driving me mad.
The space bar trick is not what I want as it gives me the impression of doing yoga with my fingers while doing some other operations.
What’s needed here is an OFF/ON switch in the menus with a keyboard shortcut and I just hope that such feature will be included in a next update, real soon, now.