Yup, I have reproduced this as well. I have filed a bug here: https://codeberg.org/wanesty/affinity-wine-docs/issues/11
On my AMD graphics machine I have found vulkan more reliable but laggier, and on my Intel integrated graphics machine I have found OpenGL to be more reliable.
I am using Affinity Designer 2.3.0 and the setup is currently using ElementalWarrior wine 8.14, but I see from above that it may be worth rebasing the patch set on newer Wine, which I might do and dump into a Git repo somewhere. I might do that and move the setup to use it if I have energy to invest in this later.
Also, for those who find Nix things pleasing to use, there is a practically one-line, reproducible, setup I've written for @Wanesty's guide here, that will build Wine for you as appropriate and do the wineprefix stuff for you pleasantly: https://github.com/lf-/affinity-crimes
