Thanks for your answer, @Seneca.
I always find hard to accept the fact that your "maybe printed in the future" work needs to be tied to specific printer's guidelines. 😀
So far these are my takes, please let me know if I am off track:
Publisher 2 seems good to put together lettering, panels, vectors, effects, arrange pages and export the final product. You might even adjust these elements at a later point if your requirements change, even if it could be a lot of work!
For the actual drawing and inking, another software supporting 1 bit layers for lineart might be ideal, or traditional paper / scan. This way all the art can independently be made and available at a bigger size, then scaled down before or after being imported into Publisher 2.
I did notice that imported lineart images retains their 1 bit (no antialiasing when zoomed in). Curiously, if I switch to Photo Persona via StudioLink, the lineart gets converted and it's antialiased. It goes back to 1 bit if switching again to Publisher or Designer.
If I got it right, @Fixx did test the monochrome issue as well. I did some print tests on my home inkjet and, apart for possibly being totally irrelevant, I am not sure how to check if it is 100k.
The last thing it's a question:
Does sending a bigger document size to the printer improve even more lines sharpness? For example send an A3 file and ask to be printed to A4, or am I talking nonsense?