I'm still fairly new to both astrophotography and Affinity Photo, and although I'm not familiar enough with Photo to attempt all the processing on it, I do use the background removal tool at some stage of the processing on pretty much every image now to help remove or reduce a colour gradient. The four attached images are examples of how this turned out. I sometimes find I can also use the vignetting tool in one form or another to help with luminance gradients. I don't really have a set workflow at the moment and hopefully as my photography techniques improve, I won't have to use trial and error to try to fix the final images.