I went through all the comments here and tried every combination and yet I still cannot figure out how to cut a simple circle shape out of a more complex image. Can someone please help? It just never gives me an option for for substract, it is always greyed out. I checked the "Fill mode" for both, circle and the earring shape. The circle is set to "Alternate", but the earring shape has no selection. Both options (alternate or winding) are greyed out. I am suspecting that this might be the reason why I cannot do substract. Is there any way of changing it or any other way of cutting out the circle?