I have a folder layout with three panels across one US 8 1/2 x 11 page, landscape, 1/4" gutters/borders.
On screen, it shows up as perfectly aligned and centered.
When printed out from PDF as a check print, it is too wide, it seems OK on the left gutter, but is almost bleeding over on the right. The two inside gutters are also shifted over from where they should be. But it is not an overall scale factor issue, since the top and bottom spacing is correct. Only the width scale or width positioning is off, and it is off quite a bit, not quite the full 1/4" gutter, but most of it. I know there is a slight error inherent in the copier style printers, so that money cannot be easily copied or printed, but this is more than that amount of error.
On screen (I am using inch units) the center column starts just left of the 4" ruler mark, and the right column is barely left of the 7.5" mark, which would be correct. the left and right gutter look correct.
This is very difficult to diagnose, since it looks fine and shows no alignment issues on-screen. I don't know if it is an issue with the output or the printer. I printed the check prints from PDF output at a regular quick printing place, which I have used before and never have seen the issue, printed on the same machine which I have used before.