Since the 1.9.1 update, launching adjustment (Levels, White Balance, etc.) can require up to 40 clicks before the adjustment box launches. I have tried the rasterize and trim option in layers, constantly saving the document before trying to select an option, but nothing seems to solve this. I am using macOS Big Sur, v. 11.2.2 on an iMac.The issue was happening before Apple did an incremental OS update last week. Having to click up to 40 times per adjustment function has destroyed my productivity. I looked through Affinity preference categories to make sure I haven't changed anything but there aren't any direct options for layer adjustments.
BTW, using the filters via the drop down menu also behaves wonky. Sometimes the selected change/adjustment is ignored and sometimes it works fine. I never had trouble using that filter adjustment portal previously. My usual working approach is to launch Affinity Publisher and then switch back-and-forth between the three personas. Before sending this bug report I tested the problem by launching my document directly with Affinity Photo, instead of within the Publisher suite method, and to my surprise adjustment panels launch either on the first click or second. Good work around but that negates the benefits of the connectivity within Publisher.