Yes I am using it with Affinity Designer. I have mapped the buttons on the tablet to Affinity actions which makes using the tablet very efficient. Other than that just load the drivers, plug it in and it works with AD.
Do be aware when you are using the brush or pen tool that you can select the Controller button in the top context menu and select "Pressure" or "Velocity" etc to decide how AD will interpret the movements or pressure of the pen. Just a feature that is not obvious if you are coming from a mouse.
I can say after using it for a day that a tablet is a HUGE improvement over a mouse. So I have an interest in learning to draw. I am no longer confined to making drawings using the geometric shape tools. I followed some advice from a Youtuber to prctice drawing circles and lines on a tablet to improve skill and just after a couple hours of doing this I can say that it does improve your dexterity.
You can use the tablet and pen for controlling your computer as well. The pen is basically recognized as mouse input when you are not i a graphics program.