Thanks, SkyHigh. Digging through the registry is beyond what I want to do for this Beta. I did try it again with the anti-virus deactivated, same Setup Failed. I'll wait until they fix it, and continue on with PagePlus for now. Edit to Add: I made a comment over on Affinity's Facebook Page about this issue, and they suggested a reboot and then run the program file As Administrator. That worked, I didn't need to do anything with the registry.
Publisher prompted me to do the update, and I got the SetUp Failed screen. The old version does not appear to be installed any longer, I downloaded a fresh copy of 227, and that failed also. I was hoping to create some ads today, but apparently I'll have to do them in PagePlus. Any suggestions? (I did try the DPI settings thing, I don't have a hi-res screen so I didn't really think that would work, and it didn't. I also tried re-installing 206, but no luck with that, either.)