Here's an interresting one:
I created some text in faux-italics by tilting the letters by 13 degrees. (My machine didn't have the italic font and I was to lazy to go and do a search for just one word, I admit).
Now, exporting to PDF worrks as expected. Printing said PDF works as expected, printing from Affinity Designer however produces weired results...
The letters dont't get tilted, instead they rotate by 13°. The printer btw is a HP Color LaserJet CP3525 UPD PCL 6.
I tried different fonts, sizes even colorspaces always with the strange outcome. The PDF export is a workaround for now, but you should look into this before alpha phase.
Aside from the little hickup, it's real fun working with publisher!