From our friend @kartoffeltree
So:
Affinity honors the (natural scrolling) system settings correctly on macOS.
Affinity flips the setting upside down in iPadOS, providing the exact opposite behavior as on macOS with the same settings.
My setup - newest macOS/iPadOS and recent hardware
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I usually use my iPad with a external monitor when I'm with clients, suppliers, partners, or traveling, and it has been hours to days since I last used my Mac, where everything works correctly. I noticed I was struggling with zooming, but I thought it was due to the alt + scrolling maneuver. If I had used them side by side, I would have understood.
Pssst Serif, you should add this to iPad editions so we can scroll without alt - it would improve workflows dramatically when using an iPad Pro with a monitor, keyboard and mouse: