Linux is on my main systems. I only do graphics work to support document creation, not as a primary task. I only keep Windows around until such time as everything runs under emulation. But let's not go into that.
If you look at Darktable and Inkscape, you at last see programs running on Linux that generate publication quality graphics. Gimp is finally stable, and a few years ago I was actually able to complete a project in Gimp without having to run back to Photoshop. There are even some nice animation programs on Linux (Tupi, Toon Boom, Open Toonz, etc.). That's not really my thing, but it shows that Linux is a graphics platform.
I like the interface and design choices made by Affinity Designer. I think it occupies a unique market niche, not just cost-wise. I'm sure that's why people keep trying to run it on Wine. It would solve a problem with very little effort.
If you look at the software examples I've listed above, you see what the Linux world does to things that it can't have. This brings me back to my original question, which is how can we have it? Or more specifically, what target do we have to hit to get it to run on Wine? I'm sure the code authors know they're doing something unusual that the emulator is having trouble with. With that piece of information, I can pester the Wine developers about what to add.