This issue is easiest to see when trying to use the brush with the Pixel Persona.
The performance slows down immensely and the canvas starts flashing when making strokes with the brush.
This is behavior that i've seen in quite a few windowed apps so it isn't unique to Affinity but I don't know if this needs to be fixed on Nvidia's side or Affinity's.
(Perhaps Affinity needs to reach out to Nvidia with this info)
This is the setting causing the issue on Gsync monitors:
(Only full screen stops the flashing and improves performance a lot, but it is still lacking compared to v1.
There is already a topic for the general slow performance though)