Thanks for all the help! Next time I encounter this I'll check and see if the layer needed to be switched to "raster". I ended up completing the task in something called Paint.net. I was worked with an imported (well either a dragged or copy/pasted in image). I don't think it's ever taken me more than a minute to figure out how to do something like this in any other program; just select an area with the magic want tool and delete it.
It was the "Assistant" I think that triggered me. I was literally almost about to throw my laptop against the wall. This wasn't the only small thing that ended up taking a lot of extra time to figure out.
I do actually have Affinity Photo (in case I actually have to use that program to complete the task) but I never guessed that I would have to switch programs for something so simple.