I have just finished building a 188 page catalogue in Publisher and so far it has worked pretty well! Apart from a few glitches, of course.
One last minute issue I ran into was PDF Export for professional print use. Unfortunately they could not get the exported PDF files through Prinergy for pre-press because of trapping errors.
The only solution to get this working was to export the PDF with all fonts converted into curves at export.
All in all I found Affinity to be a great piece of software but there really is some work left regarding PDF export and colour management for professional print use, I would say!
Using Windows 10 Pro Build 18362.592, Affinity Publisher 126.96.36.1991
Have a great evening