Hey!
Today I noticed an odd thing:
Setting up global colors in a document.
Apply it to object with multiple strokes and/or fills.
Deselect the object or switch from fill to stroke color in the color panel or the other way round.
Change the settings of a global color used in one of the strokes of the object (that is changing color values).
If the stroke of that global color is active the color changes. If another stroke is active the non-active stroke's color looses connection to the global color.
Then I have to activate it again in the appearance panel and reassign it.
Hope this it is understandable - I tried it with fills too with the same issue.
All the best,
Chris