A few betas ago I noticed, that Publisher gets a bit more unresponsive (unusable) working on the same document, like text/graphics blurred, UI sometimes completely missing, menu items not selectable etc. pp.
But there are two workarounds at least for me -> Keep Publisher busy with any kind of operation. Creating a new document with keyboard shortcuts + hitting Enter key is one workaround, the sequence hitting ESC -> H -> moving the page is the other one. Just wanted to let you know if you are facing the same problem, always force closing and restarting Publisher is not an option.
Maybe something changed inside the programmes code so that is now even more difficult to handle the 106 pages with approx. 100 - 200 layers each page. But I am confident, that Serif will give Publisher a performance boost with the final release.