For UI design, I configure reusable components, which often involves toggling layer checkboxes. I've noticed that my Mac's scroll bars frequently get in the way. So, instead of toggling a box, I fly up or down the list because I've clicked a new position on the scroll bar.
I have changed my system preferences to always show scrollbars, which fixes the problem. But optimally, the scrollbar in the Layers panel would be permanently shown regardless system preferences, so that the checkboxes don't overlap.