Spent hours trying to get Affinity Designer to work. Tried the three versions of wine 5 stable, dev and staging. I tried both the Lutris script and installing manually. It would get to installing .NET 4.xx.xx and it would get stuck in an error loop. I believe the error was something to do with NTDLL there were also a ton of fixme errors.
Running Mint 19.3, OS linux x64 // Linux 5.3.0-51-generic.
003d:err:ntdll:RtlpWaitForCriticalSection section 0x100a8 "/home/ubuntu/buildbot/runners/wine/wine-src/dlls/ntdll/heap.c: main process heap section" wait timed out in thread 003d, blocked by 01cb, retrying (60 sec)