Bromiclime

The short answer, no
The longer answer, kinda
The installer will run once you have .Net 4/4.5/4.7 installed in your Wine Prefix (used staging 3.13) and completes without any problems. Its starting it up that gets rough.
The windows version of Affinity photo requires the Windows DWM for composition of the application screen and has some custom DLLs that dont seem to happy to hook into the WINE implementation of Windows. The DLLs just straight fail to load at all and while you can get it to attempt to run switching WINE to Windows 8/10 bypassing the Aero not enabled, the application crashes just after opening.
 
I haven't done extensive testing to get it to actually open, but truth be told you likely won't see good results even if you do. It'll likely run very unstable and slow which defeats it's entire purpose. I imagine because WINE doesn't have a complete DX11 implementation, doesn't have Windows DWM, and doesn't have/implement in full/doesn't implement the exact same any number of other necessary Windows parts it's just not going to be enjoyable. I don't know exactly how ingrained in the Windows ecosystem (dlls, etc)  the windows version of Affinity Photo is but my guess is more than WINE can deal with at this time. 
 
Hope this helps anyone on Linux looking for an answer and saves you from wasting your time trying to get an application going in WINE just to have it run awful.
EDIT: some issue could be a combo of it requiring .NET Framework and a 64bit install/Prefix. Wine can be a bit sketchy with .NET in 64bit prefixes and not all functions work running .NET application. Issues could also be arising from the rendering engine not enjoying running in WINE . Ive tried everything i ccan to narrow down exactly what issues are causing the DLLs in the program folder to not load and i have to just chalk it up to "AP needs fully implemented windows"

Unix by definition is the family of OS derivative of the original ATT Bell labs, with OSx (iOS in turn) being considered the Unix with the largest install base, you can look into it if you like or believe it's not true I don't care. "Unix-like" (which really just means they didn't pay for Unix certification) systems like Linux are derivative of Unix (again responding like it,etc. But not directly using original Unix code), and in turn Android runs atop Linux.
 
Believe what you want, but that is what it is, that is part of what makes porting between them so relatively simple. I'm not much interested in simple "nope you're wrong" answers if I'm going tbh, so substantiate what you're saying besides just saying no because everything else seems to disagree with your statement.

Im sorry for the necro but this I had to comment on. 
 
This statement is pretty well wrong, unless you use a Windows phone or the cheapest garbage phone possible you guaranteed have either the Linux kernel or a Unix kernel, thats just plain fact of the matter (iOS and Linux are Unix based systems)
 
Second, Linux/Unix flat dominates the web, it runs everything minus a hand full of people running maybe windows server which I'm not 100% sure Amazon, Google, Facebook, etc., Everything you've come to use every day, the servers that got you here, all likely run Linux (and the 3 listed actually do and contribute to it) . Being conservative 90% of the web you know is Unix/Linux, 10% is Microsoft/Other. 
 
Linux isn't supported simply because of the slew of ignorance and misconception displayed throughout this thread permeates to the software industry that perpetuates these ideas. Linux isn't an unknown, it's everywhere, just not as much in homes. There isn't a reason it can't be supported, just most companies don't want to because of the idea "Linux is for nerds" and other such things expressed here. It's a mindset issue not a technical issue, period.

The short answer, no
The longer answer, kinda
The installer will run once you have .Net 4/4.5/4.7 installed in your Wine Prefix (used staging 3.13) and completes without any problems. Its starting it up that gets rough.
The windows version of Affinity photo requires the Windows DWM for composition of the application screen and has some custom DLLs that dont seem to happy to hook into the WINE implementation of Windows. The DLLs just straight fail to load at all and while you can get it to attempt to run switching WINE to Windows 8/10 bypassing the Aero not enabled, the application crashes just after opening.
 
I haven't done extensive testing to get it to actually open, but truth be told you likely won't see good results even if you do. It'll likely run very unstable and slow which defeats it's entire purpose. I imagine because WINE doesn't have a complete DX11 implementation, doesn't have Windows DWM, and doesn't have/implement in full/doesn't implement the exact same any number of other necessary Windows parts it's just not going to be enjoyable. I don't know exactly how ingrained in the Windows ecosystem (dlls, etc)  the windows version of Affinity Photo is but my guess is more than WINE can deal with at this time. 
 
Hope this helps anyone on Linux looking for an answer and saves you from wasting your time trying to get an application going in WINE just to have it run awful.
EDIT: some issue could be a combo of it requiring .NET Framework and a 64bit install/Prefix. Wine can be a bit sketchy with .NET in 64bit prefixes and not all functions work running .NET application. Issues could also be arising from the rendering engine not enjoying running in WINE . Ive tried everything i ccan to narrow down exactly what issues are causing the DLLs in the program folder to not load and i have to just chalk it up to "AP needs fully implemented windows"

The short answer, no
The longer answer, kinda
The installer will run once you have .Net 4/4.5/4.7 installed in your Wine Prefix (used staging 3.13) and completes without any problems. Its starting it up that gets rough.
The windows version of Affinity photo requires the Windows DWM for composition of the application screen and has some custom DLLs that dont seem to happy to hook into the WINE implementation of Windows. The DLLs just straight fail to load at all and while you can get it to attempt to run switching WINE to Windows 8/10 bypassing the Aero not enabled, the application crashes just after opening.
 
I haven't done extensive testing to get it to actually open, but truth be told you likely won't see good results even if you do. It'll likely run very unstable and slow which defeats it's entire purpose. I imagine because WINE doesn't have a complete DX11 implementation, doesn't have Windows DWM, and doesn't have/implement in full/doesn't implement the exact same any number of other necessary Windows parts it's just not going to be enjoyable. I don't know exactly how ingrained in the Windows ecosystem (dlls, etc)  the windows version of Affinity Photo is but my guess is more than WINE can deal with at this time. 
 
Hope this helps anyone on Linux looking for an answer and saves you from wasting your time trying to get an application going in WINE just to have it run awful.
EDIT: some issue could be a combo of it requiring .NET Framework and a 64bit install/Prefix. Wine can be a bit sketchy with .NET in 64bit prefixes and not all functions work running .NET application. Issues could also be arising from the rendering engine not enjoying running in WINE . Ive tried everything i ccan to narrow down exactly what issues are causing the DLLs in the program folder to not load and i have to just chalk it up to "AP needs fully implemented windows"

The short answer, no
The longer answer, kinda
The installer will run once you have .Net 4/4.5/4.7 installed in your Wine Prefix (used staging 3.13) and completes without any problems. Its starting it up that gets rough.
The windows version of Affinity photo requires the Windows DWM for composition of the application screen and has some custom DLLs that dont seem to happy to hook into the WINE implementation of Windows. The DLLs just straight fail to load at all and while you can get it to attempt to run switching WINE to Windows 8/10 bypassing the Aero not enabled, the application crashes just after opening.
 
I haven't done extensive testing to get it to actually open, but truth be told you likely won't see good results even if you do. It'll likely run very unstable and slow which defeats it's entire purpose. I imagine because WINE doesn't have a complete DX11 implementation, doesn't have Windows DWM, and doesn't have/implement in full/doesn't implement the exact same any number of other necessary Windows parts it's just not going to be enjoyable. I don't know exactly how ingrained in the Windows ecosystem (dlls, etc)  the windows version of Affinity Photo is but my guess is more than WINE can deal with at this time. 
 
Hope this helps anyone on Linux looking for an answer and saves you from wasting your time trying to get an application going in WINE just to have it run awful.
EDIT: some issue could be a combo of it requiring .NET Framework and a 64bit install/Prefix. Wine can be a bit sketchy with .NET in 64bit prefixes and not all functions work running .NET application. Issues could also be arising from the rendering engine not enjoying running in WINE . Ive tried everything i ccan to narrow down exactly what issues are causing the DLLs in the program folder to not load and i have to just chalk it up to "AP needs fully implemented windows"

Hi folks, preferred name is Echoa (said like "Echo")
 
Im more of a hobbyist when it come to digital art, more recently with a heavier focus on photography with my main passion being tech/computers (hardware and software but more so hardware). I was using Adobe CC for about 5yrs now but got tired of a subscription and the extra in it that i never used but was paying for with what appeared to be little other option. Stumbled upon Affinity Photo and gave the trial a go, needless to say i fell for it immediately its a fantastic bit of software. I have already canceled my CC sub and moved to a combo of Affinity Photo + Aftershot Pro with Krita being my drawing application now that Autodesk moved Sketchbook Pro ot a sub model also (really unfortunate).
 
Glad to a see a healthy forum for AP, look forward to not knowing how to do something and getting some help lol and maybe in the future if affinity makes something more like lightroom/aftershot pro ill get that too. Keep up the good work guys