This change made the application almost unusable for my daily workflow. Since the path the application is installed to is locked away by Windows, even to administrator accounts, a lot of application can't launch it externally.
E.g. Unity3D will not allow me to mark Affinity as my external image editor, which means I can no longer open images directly from Unity3D, which is how I use Affinity 99% of the time.
The Stream Deck also can't launch the application anymore. You have to find a hidden folder in windows (not the actual application path), find the app and create a shortcut, which Windows will not allow and ask to place to place it on the desktop, which you can then link to. That workaround took me a while to figure out, considering what a simple task it should've been.