As the subject line implies, this bug appears in the Pixel persona while using the Paint Brush Tool. This is intermittent though fairly consistent and seems to occur in this one file only.
Based on troubleshooting, here is what I have been able to determine.
While working on a Pixel layer at the Master/Root level, there are no issues.
If the Pixel layer is nested under another Pixel Layer (as a Clipping Mask), under a Layer, or in a Group, the issue will appear intermittently. The issue being that the line will stop rendering while being drawn (it will have a blocky pixelated edge and continual drawing in the affected area does not fix or change anything)
If any of the following is done, then line will appear either partially or fully
Moving the cursor over the affected area will cause the line to appear wherever the cursor has been
Zooming in or out will cause the entire unrendered line to appear
Moving the Pixel layer out from under the parent Layer or Group to the master/root level
Hardware Acceleration is disabled currently and enabling it causes AD to crash without warning.
Attached is the affected .afdesign file and screenshots showing before and after a zoom to have lines appear and moving the cursor over an affected area to have lines appear wherever the cursor was.
Before
After
Cursor moved over non-rendering area
Jojo Ginga.afdesign