Hi, I am also getting issues when scanning from within Affinity Photo (v1.9.3). I'm currently using a Canon CanoScan LiDE 400 scanner, using the latest drivers running on macOS Big Sur 11.4 . Scanning is perfect when using the Canon IJ Scan Utility or Apples own Image Capture app. I noticed that when AP is opened and 'Aquire Image' selected for the first time, an error message appears 'Failed to open a session on the device. (-9921)'; the window then closes. The overview/preview image is perfect, but when a scan is actioned, the output is garbled similar to futuraprime's post. I've tried most options to try and resolve the issue - removing printers/scanners, reset the printing system and reinstalling all printers/scanners. Sadly, same results occur. Thank you in advance for any help with this problem.