Update, Daniel's fix seems to have improved things by quite a bit. There is still a difference between the navigator and the main window but it is close to negligible now. For example in my test I filled with main window with rgb: 235, 67, 40 and the navigator preview is rgb: 235, 67, 38. I am assuming this is just a byproduct of the compression on the navigator image as it is so tiny that it is no longer visibly different. I'd consider this issue solved. Albeit I am still miffed as to why the display's color profile impacts the main window but not the navigator. I had assumed early on that if the issue was display color profile related that it would universally impact everything.
Big thanks to Daniel for figuring this out. You deserve many cookies.
rcooper102 got a reaction from Daniel Tudosiu in Affinity Photo main editor window colors are incorrect. (and inconsistent with navigator)