That's another bug. I tried to save with a selection, and yes, the Histogram fails on the next load, until the marquee is deselected. But that's not a serious problem though.
What I'm experienced is that I cannot see the Histogram of a certain marquee selection. However I try, it just doesn't work.
This time I tried to save with or without a marquee selection, and with or without the "Marquee" option selected, the problem remains.
Also, I converted the document into RGB 8, the problem remains, I will attach the .afphoto file here.
The first video is when I try to save with or without a marquee selection.
The second video is when I convert it into RGB 8.
save_with_selection.mp4
convert_to_rgb.mp4
bug_reproduce_RGB.afphoto