[Subtracting text layers to leave transparent background]

I am trying to take two different letters (on separate layers) and subtract one letter from the other to leave a transparent "hole" in one of them.  What I want to do is create a capital "R" and delete the shape of a lower case "s" so the background shows through on a T-shirt design.  I have been trying to do this in affinity designer and I also have affinity photo so whatever software is easier to use is fine with me. Ultimately I need them in a vector format to be resized as part of a logo. Thank you in advance for your help!