Photoshop and PSE can both crop multiple photos scanned together (as can Irfanview and Imagemagick), but if you have thousands of photos, you'll need a script to batch crop them. Otherwise, cropping and saving a large number of "multi-scans" will still require a lot of time and repetitive effort. Mac users can use an app called SnipTag: You scan up to eight photos at a time with any scanner or camera in JPG, PNG, TIFF or BMP formats. Import multiple such scans into the app, and it crops the entire batch. The app isn't free, but I found it worthwhile for a large family photos scanning project.
