I was having an identical issue to Kdiver25, and realized that you can set the blend mode to "erase". It will create a transparent cutout in the shape below it. It works just like the "subtract" function that most people are used to, but it's even more convenient because it's non-destructive. This still doesn't help if you are required to expand all strokes for publishing, though.
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Although the above worked for me in this case, I also had to find a workaround for a different part of my project because I couldn't expand a brush stroke, nor create a custom true vector brush. I would consider that a pretty essential feature in a professional workflow, and I look forward to seeing it eventually implemented.